A groundbreaking podcast delves into the innovative use of deep brain stimulation (DBS) as a treatment for depression, offering hope to those grappling with this debilitating mental health condition. Supported by PRX, the John S. and James L. Knight Foundation, and the Burroughs Wellcome Fund, the podcast explores the history and evolution of DBS through expert insights and personal stories. Neurologist Helen Mayberg, a pioneer in the field, shares her expertise alongside poignant testimonies from Jon Nelson and Amanda, two individuals who have undergone DBS treatment.
Amanda's journey with depression began at the tender age of 13. Over a decade, she tried 21 different antidepressants, spending six weeks hospitalized and another six weeks in an outpatient program. Her struggle with depression was profound, leaving her searching for a solution when traditional treatments failed. Jon Nelson's experience mirrored Amanda's in intensity, as his depression not only took a toll on his mental well-being but also severely impacted his physical health. Often finding himself bedridden or numbing his mind with endless television, Jon described his depression as a pervasive poison coursing through his veins.
"It literally ran throughout every cell in my body. My blood carried the poison, and it crushed everything in me." – Jon Nelson
Both Amanda and Jon participated in a DBS research program that marked a significant advancement over previous versions. The new approach was more precise and targeted, aiming to implant electrodes in specific areas of the brain to stimulate mood improvement. For Amanda, this treatment represented a considerable improvement over past attempts to manage her depression, which had left her feeling trapped.
"You're, there's a lightness. It's, it's a clearing." – Amanda
Despite the promise of DBS, it remains clear that this treatment is not a cure for depression but rather a tool to help manage its symptoms. The Broaden trial, a six-month study involving 90 individuals with severe depression, revealed that those with their stimulation on were no better off than those without it by the end of the trial period. This underscores the complexity of treating depression and the ongoing need for research and refinement in therapies like DBS.
Amanda's experience with DBS was not without challenges. While she found relief from her symptoms, she also suffered memory damage as a side effect. Yet, she remains steadfast in using her art to cope with her condition. Her drawings often feature "Cartoon Amanda," a character through which she channels her emotions and experiences.
Jon's journey with DBS also involved emotional hurdles. His wife, Barbara, initially feared the risks associated with the procedure. However, Jon reassured her that this step was necessary for his well-being.
"You feel it physically in your body. I felt that all the time, but it felt like death. It felt like dread. It felt like a massive blanket of hell literally on my body and inside of me at all times. And it never left." – Jon Nelson
The podcast aims to shed light on the realities of living with depression and the importance of seeking help. It serves as a poignant reminder that support is available for those in crisis, encouraging listeners to reach out to resources like the 988 Suicide and Crisis Lifeline.
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